Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 8/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.54 |
| ▸ | HTR3B | O95264 | 3/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6009255 | 0.92 | CHRNA7 (0.57) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6008903 | 0.90 | HTR3A (0.54) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6008956 | 0.84 | CHRNA7 (0.37) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6008824 | 0.84 | CHRNA7 (0.53) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6008895 | 0.83 | CHRNA7 (0.54) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6007906 | 0.82 | CHRNA7 (0.48) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6007771 | 0.80 | CHRNA7 (0.56) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6007596 | 0.78 | CHRNA7 (0.43) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL6008979 | 0.76 | CHRNA7 (0.39) | HTR3ACHRNA7HTR3EHTR3BHTR3D | |
| SCHEMBL5704884 | 0.76 | HTR3A (0.69) | HTR3ACHRNA7HTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067515-B2 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PFIZER INC. (US) | 2006-06-27 | — | — | US | claimed |