Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6009269 | 0.83 | OPRM1 (0.54) | KMT2AMEN1ALDH1A1RECQLRAB9A | |
| Bromide SCHEMBL6009286 | 0.82 | OPRM1 (0.46) | KMT2AMEN1ALDH1A1RECQLRAB9A | |
| Hydrochloric Acid SCHEMBL7421854 | 0.81 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1RECQLRAB9A | |
| Hydrochloric Acid SCHEMBL3844254 | 0.78 | ALDH1A1 (0.46) | KMT2AMEN1ALDH1A1RECQLRAB9A | |
| Bromide SCHEMBL6074531 | 0.78 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1RECQLRAB9A | |
| SCHEMBL23752059 | 0.76 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1RECQLRAB9A | |
| SCHEMBL18745980 | 0.76 | RAB9A (0.55) | KMT2AMEN1ALDH1A1RECQLRAB9A | |
| Hydrochloric Acid SCHEMBL3845958 | 0.75 | RAB9A (0.54) | KMT2AMEN1ALDH1A1RECQLRAB9A | |
| Bromide SCHEMBL6010208 | 0.73 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1RECQLRAB9A | |
| Bromide SCHEMBL6009336 | 0.73 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1RECQLRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368029-A4 | METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS | FARRINGTON PHARMACEUTICALS LLC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1368029-A2 | METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS | Farrington Pharmaceuticals, LLC (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002062301-A2 | METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS | FARRINGTON PHARMACEUTICALS, LLC (US) | 2002-08-15 | — | — | WO | disclosed |