⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6009645 | 1.00 | — | — | |
| SCHEMBL3945125 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL31436727 | 0.97 | TDP1 (0.37) | — | |
| SCHEMBL11774866 | 0.88 | LMNA (0.35) | — | |
| SCHEMBL9134947 | 0.82 | CA2 (0.42) | — | |
| SCHEMBL9134940 | 0.82 | CA2 (0.42) | — | |
| SCHEMBL4406288 | 0.80 | — | — | |
| SCHEMBL8977568 | 0.76 | TDP1 (0.39) | — | |
| SCHEMBL18595961 | 0.76 | KDM1A (0.30) | — | |
| SCHEMBL784180 | 0.74 | CA14 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4855455-A | Preparation of amino acid derivatives | W. R. GRACE & CO.-CONN. (US) | 1989-08-08 | — | — | US | claimed |
| US-20180148457-A1 | FUSED HETEROCYCLIC COMPOUNDS AS CAM KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-05-31 | — | — | US | disclosed |
| US-8552205-B2 | Derivatives of 6,7-dihydro-5H-imidazo[1,2-alpha]imidazole-3-carboxylic acid amides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-08 | — | — | US | disclosed |
| US-8552205-B2 | Derivatives of 6,7-dihydro-5H-imidazo[1,2-alpha]imidazole-3-carboxylic acid amides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-08 | — | — | US | disclosed |
| US-20110224188-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-15 | — | — | US | disclosed |
| EP-1713781-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005075439-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |
| EP-0325485-B1 | Preparation of amino acid derivatives | HAMPSHIRE CHEMICAL CORP (US) | 1994-08-03 | — | — | EP | disclosed |
| US-4855455-A | Preparation of amino acid derivatives | W. R. GRACE & CO.-CONN. (US) | 1989-08-08 | — | — | US | disclosed |
| EP-0325485-A2 | Preparation of amino acid derivatives | HAMPSHIRE CHEMICAL CORPORATION (US) | 1989-07-26 | — | — | EP | disclosed |