Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27577813 | 0.84 | ESR1 (0.49) | ESR1ESR2MAOBHSD17B10MAPK1 | |
| SCHEMBL16391312 | 0.80 | MAOB (0.41) | ESR1ESR2MAOBHSD17B10MAPK1 | |
| SCHEMBL12583780 | 0.77 | HSD17B10 (0.46) | ESR1ESR2MAOBHSD17B10KDM4E | |
| SCHEMBL6010882 | 0.74 | ESR1 (0.39) | ESR1ESR2 | |
| SCHEMBL23315376 | 0.74 | CA12 (0.42) | ESR1ESR2HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL21487412 | 0.74 | MAOB (0.43) | ESR1ESR2MAOBHSD17B10ALDH1A1 | |
| SCHEMBL16047286 | 0.72 | ESR2 (0.47) | ESR1ESR2HSD17B10MAPK1KDM4E | |
| SCHEMBL5021458 | 0.72 | NUDT1 (0.41) | MAPK1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6010802 | 0.70 | LMNA (0.43) | HSD17B10KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21487580 | 0.69 | MAOB (0.43) | ESR1ESR2MAOBHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3020718-B1 | NOVEL PDE4 INHIBITOR | MEIJI SEIKA PHARMA CO LTD (JP) | 2018-12-26 | — | — | EP | disclosed |
| US-9890142-B2 | PDE4 inhibitor | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2018-02-13 | — | — | US | disclosed |
| US-9850235-B2 | — | — | 2017-12-26 | — | — | US | disclosed |
| US-20160159783-A1 | PDE4 Inhibitor | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2016-06-09 | — | — | US | disclosed |
| EP-3020718-A1 | NOVEL PDE4 INHIBITOR | Meiji Seika Pharma Co., Ltd. (JP) | 2016-05-18 | — | — | EP | disclosed |
| US-7045516-B1 | Benzoxazole derivatives and drugs containing the same as the active ingredient | KOICHI SHUDO (JP) | 2006-05-16 | — | — | US | disclosed |
| EP-1134220-B1 | BENZOXAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | SHUDO KOICHI (JP) | 2004-08-18 | — | — | EP | disclosed |
| CN-1333771-A | Benzoxazole derivative and drug containing the same as active ingredient | MEIJI SEIKA KAISHA (JP) | 2002-01-30 | — | — | CN | disclosed |
| EP-1134220-A1 | BENZOXAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | MEIJI SEIKA KAISHA LTD. (JP) | 2001-09-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159783-A1 | PDE4 Inhibitor | PDE4A, PDE4B, PDE3B | ESR1 3756/4885ESR2 3137/4885MAOB 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.