Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320148 | 0.74 | PLA2G7 (0.36) | MEN1KMT2ACYP1A2CYP2C19HPGD | |
| SCHEMBL12326180 | 0.72 | CA1 (0.50) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL17178230 | 0.70 | CYP1A2 (0.48) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL1459479 | 0.69 | ACHE (0.40) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL130126 | 0.68 | MCL1 (0.52) | MEN1KMT2AMAPTCYP1A2RAB9A | |
| SCHEMBL8064215 | 0.68 | MAPT (0.37) | MEN1KMT2AMAPTCYP3A4NPSR1 | |
| SCHEMBL30532385 | 0.68 | MEN1 (0.43) | MEN1KMT2AMAPTCYP1A2CYP3A4 | |
| SCHEMBL11595939 | 0.68 | HSP90AA1 (0.42) | MEN1KMT2AMAPTCYP3A4NPSR1 | |
| SCHEMBL10621165 | 0.68 | NOTUM (0.39) | CYP3A4HSP90AA1HSP90AB1CRHR1 | |
| SCHEMBL3011523 | 0.68 | MAOB (0.41) | MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425280-B1 | HETERO-BICYCLIC CRF ANTAGONISTS | GLAXO GROUP LTD (GB) | 2006-08-30 | — | — | EP | claimed |