Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 16/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.48 |
| ▸ | CCL5 | P13501 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6011408 | 0.86 | CCR5 (0.53) | CCR5KCNH2CCL5 | |
| SCHEMBL6011793 | 0.84 | CCR5 (0.55) | CCR5KCNH2CCL5 | |
| SCHEMBL6011790 | 0.84 | CCR5 (0.55) | CCR5KCNH2CCL5 | |
| SCHEMBL6011413 | 0.84 | CCR5 (0.47) | CCR5KCNH2CCL5 | |
| SCHEMBL6011412 | 0.84 | CCR5 (0.47) | CCR5KCNH2CCL5 | |
| SCHEMBL6011682 | 0.82 | CCR5 (0.51) | CCR5KCNH2CCL5 | |
| SCHEMBL6011558 | 0.82 | CCR5 (0.54) | CCR5KCNH2CCL5 | |
| SCHEMBL6011555 | 0.82 | CCR5 (0.54) | CCR5KCNH2CCL5 | |
| SCHEMBL6011684 | 0.82 | CCR5 (0.51) | CCR5KCNH2CCL5 | |
| SCHEMBL6470114 | 0.79 | DRD2 (0.49) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060189650-A1 | Novel piperidine derivatives as modulators of chemokine receptor ccr5 | ASTRAZENECA AB (SE) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189650-A1 | Novel piperidine derivatives as modulators of chemokine receptor ccr5 | CCR5, CCR2, CCR1 | CCR5 1/4885KCNH2 2437/4885CCL5 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.