⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5704665 | 1.00 | — | — | |
| SCHEMBL6011499 | 1.00 | — | — | |
| Trifluoroacetic Acid SCHEMBL2267588 | 0.83 | ALDH1A1 (0.44) | — | |
| Trifluoroacetic Acid SCHEMBL7440809 | 0.80 | ALDH1A1 (0.42) | — | |
| Trifluoroacetic Acid SCHEMBL5608598 | 0.80 | ALDH1A1 (0.42) | — | |
| Trifluoroacetic Acid SCHEMBL5608594 | 0.80 | ALDH1A1 (0.42) | — | |
| SCHEMBL24799610 | 0.78 | ALDH1A1 (0.40) | — | |
| SCHEMBL15210201 | 0.78 | ALDH1A1 (0.40) | — | |
| SCHEMBL6439208 | 0.78 | ALDH1A1 (0.40) | — | |
| SCHEMBL5963798 | 0.78 | THRB (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110437297-B9 | Inhibitors of farnesoid X receptor and use in medicine | 美国卫生和人力服务部 | 2022-01-11 | — | — | CN | claimed |
| CN-110437297-B | Inhibitors of farnesoid X receptor and use in medicine | 美国卫生和人力服务部 | 2021-12-21 | — | — | CN | claimed |
| US-10233209-B2 | Inhibitors of the farnesoid x receptor and uses in medicine | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-03-19 | — | — | US | claimed |
| US-20170152283-A1 | INHIBITORS OF THE FARNESOID X RECEPTOR AND USES IN MEDICINE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2017-06-01 | — | — | US | claimed |
| US-20160159851-A1 | INHIBITORS OF THE FARNESOID X RECEPTOR AND USES IN MEDICINE | The United Sates of America, as Represented by the Secretary, Department of Health and Human Service (US) | 2016-06-09 | — | — | US | claimed |
| EP-3027637-A2 | INHIBITORS OF THE FARNESOID X RECEPTOR AND USES IN MEDICINE | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) | 2016-06-08 | — | — | EP | claimed |
| WO-2015017813-A2 | INHIBITORS OF THE FARNESOID X RECEPTOR AND USES IN MEDICINE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2015-02-05 | — | — | WO | claimed |
| CN-110437297-B9 | Inhibitors of farnesoid X receptor and use in medicine | 美国卫生和人力服务部 | 2022-01-11 | — | — | CN | disclosed |
| CN-110437297-B | Inhibitors of farnesoid X receptor and use in medicine | 美国卫生和人力服务部 | 2021-12-21 | — | — | CN | disclosed |
| US-10233209-B2 | Inhibitors of the farnesoid x receptor and uses in medicine | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-03-19 | — | — | US | disclosed |
| CN-105392363-B | Sample Fixation and Stabilization | A·S·戈尔兹伯勒 | 2017-09-29 | — | — | CN | disclosed |
| US-20170152283-A1 | INHIBITORS OF THE FARNESOID X RECEPTOR AND USES IN MEDICINE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2017-06-01 | — | — | US | disclosed |
| US-20170152566-A1 | GENE SEQUENCE VARIANCES IN GENES RELATED TO FOLATE METABOLISM HAVING UTILITY IN DETERMINING THE TREATMENT OF DISEASE | Body Sync, Inc. (US) | 2017-06-01 | — | — | US | disclosed |
| US-20050112680-A1 | Gene sequence variances in genes related to folate metabolism having utility in determining the treatment of disease | VARIAGENICS, A DELWARE CORPORATION | 2005-05-26 | — | — | US | disclosed |
| US-6759200-B1 | FOR ESTABLISHING DIAGNOSTIC TESTS USEFUL FOR IMPROVING THE DEVELOPMENT AND USE OF PHARMACEUTICAL PRODUCTS IN CLINICAL SETTING | NUVELO, INC. | 2004-07-06 | — | — | US | disclosed |
| US-6664062-B1 | Determining if a sample comprises a nucleic acid molecule that hybridizes to a probe comprising a specific nucleotide sequence | NUVELO, INC. | 2003-12-16 | — | — | US | disclosed |
| US-6537759-B1 | Identification of gene sequence variances useful in therapeutics; optimizing the efficacy and safety of drugs; diagnostic tests for drug development | VARIAGENICS, INC. | 2003-03-25 | — | — | US | disclosed |
| US-20020039990-A1 | Gene sequence variances in genes related to folate metabolism having utility in determining the treatment of disease | VARIAGENICS, INC. | 2002-04-04 | — | — | US | disclosed |
| EP-1100964-A1 | GENE SEQUENCE VARIANCES WITH UTILITY IN DETERMINING THE TREATMENT OF DISEASE | Variagenics, Inc. (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000004194-A1 | GENE SEQUENCE VARIANCES WITH UTILITY IN DETERMINING THE TREATMENT OF DISEASE | VARIAGENICS, INC. (US) | 2000-01-27 | — | — | WO | disclosed |