Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | NQO2 | P16083 | 6/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.44 |
| ▸ | F2 | P00734 | 3/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | C1S | P09871 | 1/20 | 0.44 |
| ▸ | CPN1 | P15169 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13073529 | 0.84 | MEN1 (1.00) | MEN1CYP1A2KMT2AGRM5GRM1 | |
| SCHEMBL8905131 | 0.81 | MEN1 (0.47) | MEN1CYP1A2KMT2ANQO2PRSS1 | |
| Hydrochloric Acid SCHEMBL8500969 | 0.80 | KMT2A (0.46) | MEN1CYP1A2KMT2ANQO2PRSS1 | |
| SCHEMBL27338628 | 0.79 | MEN1 (0.71) | MEN1CYP1A2KMT2A | |
| SCHEMBL8503418 | 0.78 | MEN1 (0.45) | MEN1CYP1A2KMT2ANQO2PRSS1 | |
| SCHEMBL305912 | 0.78 | CYP1A2 (0.70) | MEN1CYP1A2KMT2AGRM5GRM1 | |
| SCHEMBL2089243 | 0.78 | CYP1A2 (0.70) | MEN1CYP1A2KMT2AGRM5GRM1 | |
| SCHEMBL2089245 | 0.78 | CYP1A2 (0.70) | MEN1CYP1A2KMT2AGRM5GRM1 | |
| SCHEMBL7742622 | 0.77 | MEN1 (0.69) | MEN1CYP1A2KMT2A | |
| SCHEMBL21767930 | 0.77 | MEN1 (0.69) | MEN1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025120038-A1 | METHOD AND DEVICES FOR DETECTING A FIBRINOGEN LEVEL IN A SAMPLE | ROCHE DIAGNOSTICS GMBH (DE) | 2025-06-12 | — | — | WO | disclosed |
| US-20160257708-A1 | ACYLATED 4-AMIDINO- AND 4-GUANIDINOBENZYLAMINES FOR THE INHIBITION OF PLASMA KALLIKREIN | CURACYTE CHEMISTRY GMBH (DE) | 2016-09-08 | — | — | US | disclosed |
| US-9365613-B2 | Acylated 4-amidino- and -4-guanidinobenzylamines for inhibition of plasma kallikrein | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2016-06-14 | — | — | US | disclosed |
| US-20060148901-A1 | Acylated 4-amidino-and-4-guanidinobenzylamines for inhibition of plasma kallikrein | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148901-A1 | Acylated 4-amidino-and-4-guanidinobenzylamines for inhibition of plasma kallikrein | F12, F11, F2 | MEN1 1307/4885CYP1A2 1363/4885KMT2A 372/4885 |
| US-20160257708-A1 | ACYLATED 4-AMIDINO- AND 4-GUANIDINOBENZYLAMINES FOR THE INHIBITION OF PLASMA KALLIKREIN | F12, F2, F11 | MEN1 1321/4885CYP1A2 1369/4885KMT2A 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.