Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616258 | 0.80 | KMT2A (0.60) | KMT2AMEN1MAPTTDP1SLC6A2 | |
| SCHEMBL24269953 | 0.78 | MAPT (0.54) | KMT2AMAPTTDP1SLC6A2SLC6A3 | |
| SCHEMBL24414105 | 0.76 | TDP1 (0.50) | KMT2AMAPTTDP1SLC6A2SLC6A3 | |
| SCHEMBL25682098 | 0.75 | RAB9A (0.54) | KMT2AMAPTTDP1SLC6A2SLC6A3 | |
| SCHEMBL6012026 | 0.75 | TSHR (0.43) | MAPTDHFRLMNANPSR1 | |
| SCHEMBL3352990 | 0.74 | POLB (0.57) | KMT2AMAPTTDP1SLC6A2SLC6A3 | |
| SCHEMBL21095221 | 0.74 | TDP1 (0.64) | KMT2AMAPTTDP1SLC6A2SLC6A3 | |
| SCHEMBL24414096 | 0.73 | TDP1 (0.51) | KMT2AMEN1MAPTTDP1SLC6A2 | |
| SCHEMBL6011978 | 0.73 | ALDH1A1 (0.49) | KMT2AMEN1MAPTPOLBDHFR | |
| SCHEMBL24674211 | 0.72 | EGLN1 (0.44) | KMT2AMAPTTDP1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701957-A1 | 2-AMINO-O4-SUBSTITUTED PTERIDINES AND THEIR USE AS INACTIVATORS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005068465-A1 | 2-AMINO-O4-SUBSTITUTED PTERIDINES AND THEIR USE AS INACTIVATORS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-07-28 | — | — | WO | disclosed |