Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9079552 | 0.91 | PDE4D (0.60) | PDE4DADORA3NPSR1ALDH1A1MAPT | |
| SCHEMBL7510715 | 0.82 | PDE4D (0.45) | PDE4DADORA3NPSR1ALDH1A1MAPT | |
| SCHEMBL6013476 | 0.82 | ADORA1 (0.56) | PDE4DADORA3NPSR1ALDH1A1MAPT | |
| SCHEMBL8315668 | 0.79 | ALDH1A1 (0.46) | PDE4DADORA3NPSR1ALDH1A1MAPT | |
| SCHEMBL8313649 | 0.77 | ALDH1A1 (0.47) | PDE4DADORA3NPSR1ALDH1A1MAPT | |
| SCHEMBL8311271 | 0.76 | KMT2A (0.48) | NPSR1ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL24442197 | 0.75 | MEN1 (0.44) | NPSR1ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL8315473 | 0.75 | ALDH1A1 (0.48) | NPSR1ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL8316470 | 0.74 | NPSR1 (0.40) | PDE4DADORA3NPSR1ALDH1A1MAPT | |
| SCHEMBL7516958 | 0.74 | PDE4D (0.45) | PDE4DADORA3NPSR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6987105-B2 | Synthesis and use of thienotriazolodiazepines | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2006-01-17 | — | — | US | disclosed |
| US-20030229078-A1 | Synthesis and use of thienotriazolodiazepines | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229078-A1 | Synthesis and use of thienotriazolodiazepines | TBXAS1, TBXA2R, P2RY10 | PDE4D 572/4885ADORA3 578/4885NPSR1 1576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.