Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025670 | 0.84 | KMT2A (0.42) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL5024150 | 0.75 | KMT2A (0.40) | KMT2AMEN1ALDH1A1DRD2NPSR1 | |
| SCHEMBL5024145 | 0.75 | KMT2A (0.40) | KMT2AMEN1ALDH1A1DRD2NPSR1 | |
| SCHEMBL5024050 | 0.73 | HTT (0.53) | KMT2AMEN1ALDH1A1HPGDNPSR1 | |
| SCHEMBL5024109 | 0.73 | CHRM4 (0.39) | KMT2AMEN1ALDH1A1DRD2POLB | |
| SCHEMBL5025785 | 0.71 | SIGMAR1 (0.38) | KMT2AMEN1ALDH1A1HPGDNPSR1 | |
| SCHEMBL5025524 | 0.68 | KMT2A (0.43) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL2542380 | 0.68 | SMYD3 (0.48) | KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL103961 | 0.66 | — | — | |
| SCHEMBL1292139 | 0.66 | VCP (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667962-A1 | AMINOALKYLAMIDE SUBSTITUTED CYCLOHEXYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005028427-A1 | AMINOALKYLAMIDE SUBSTITUTED CYCLOHEXYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-31 | — | — | WO | disclosed |