Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 17/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6013814 | 0.83 | PGR (0.55) | PGR | |
| SCHEMBL6013862 | 0.82 | PGR (0.46) | PGR | |
| SCHEMBL6013864 | 0.82 | PGR (0.46) | PGR | |
| SCHEMBL6013825 | 0.81 | PGR (0.46) | PGR | |
| SCHEMBL6013853 | 0.81 | PGR (0.46) | PGR | |
| SCHEMBL4101242 | 0.81 | PGR (0.72) | PGRTDP2 | |
| SCHEMBL4101246 | 0.81 | PGR (0.72) | PGRTDP2 | |
| SCHEMBL6013826 | 0.77 | PGR (0.37) | PGR | |
| SCHEMBL6013828 | 0.77 | PGR (0.37) | PGR | |
| SCHEMBL3521989 | 0.77 | PGR (1.00) | PGRTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091234-B2 | Thio-oxindole derivatives | WYETH (US) | 2006-08-15 | — | — | US | disclosed |
| US-6946454-B2 | Thio-oxindole derivatives | WYETH (US) | 2005-09-20 | — | — | US | disclosed |
| US-20050171186-A1 | 3-(1',2'-Dihydro-2'-thioxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)benzonitrile; 5'-(5-Cyano-1-methyl-1H-pyrrol-2-yl)spiro[cyclohexane-1,3'-[3H]indol]-2'-ylidenecyanamide; progesterone receptor agonist; mixture with estrone (estrogen); hormone replacement therapy, contraception; anticarcinogenic | WYETH (US) | 2005-08-04 | — | — | US | disclosed |
| US-20050054711-A1 | Thio-oxindole derivatives | WYETH | 2005-03-10 | — | — | US | disclosed |
| US-6841568-B2 | Thio-oxindole derivatives | WYETH (US) | 2005-01-11 | — | — | US | disclosed |
| US-20030225109-A1 | Thio-oxindole derivatives | WYETH (US) | 2003-12-04 | — | — | US | disclosed |
| US-6583145-B1 | Thio-oxindole derivatives | WYETH | 2003-06-24 | — | — | US | disclosed |
| US-6521657-B2 | Indole derivatives which are agonists of the progesterone receptor and useful for treatment of carcinoma and adenocarcinomas of uterine leiomyomata, endometriosis or polycystic ovary syndorme in a mammal | WYETH | 2003-02-18 | — | — | US | disclosed |
| US-20020169198-A1 | Thio-oxindole derivatives | WYETH (US) | 2002-11-14 | — | — | US | disclosed |
| US-20020103248-A1 | Thio-oxindole derivatives | WYETH LLC | 2002-08-01 | — | — | US | disclosed |
| US-6355648-B1 | COMPOUNDS AS CONTRACEPTIVES AND PROGESTERONE ANTAGONIST | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103248-A1 | Thio-oxindole derivatives | PGR, OXTR, PGRMC1 | PGR 1/4885KDM4E 2520/4885ALDH1A1 840/4885 |
| US-20030225109-A1 | Thio-oxindole derivatives | PGR, OXTR, PGRMC1 | PGR 1/4885KDM4E 3083/4885ALDH1A1 634/4885 |
| US-20050171186-A1 | 3-(1',2'-Dihydro-2'-thioxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)benzonitrile; 5'-(5-Cyano-1-methyl-1H-pyrrol-2-yl)spiro[cyclohexane-1,3'-[3H]indol]-2'-ylidenecyanamide; progesterone receptor agonist; mixture with estrone (estrogen); hormone replacement therapy, contraception; anticarcinogenic | PGR, ESR1, PGRMC1 | PGR 1/4885KDM4E 1129/4885ALDH1A1 395/4885 |
| US-20020169198-A1 | Thio-oxindole derivatives | GPER1, PGR, ESR1 | PGR 2/4885KDM4E 2896/4885ALDH1A1 373/4885 |
| US-20050054711-A1 | Thio-oxindole derivatives | PGR, OXTR, PGRMC1 | PGR 1/4885KDM4E 2457/4885ALDH1A1 1126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.