Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MYOC | Q99972 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2885990 | 0.85 | MAPT (0.56) | MEN1KMT2AKDM4ESRD5A2MAPT | |
| SCHEMBL264541 | 0.83 | MEN1 (1.00) | MEN1KMT2AKDM4ESRD5A2MAPT | |
| SCHEMBL28068268 | 0.83 | PARP15 (0.55) | MEN1KMT2AKDM4ESRD5A2ALDH1A1 | |
| SCHEMBL3485184 | 0.82 | PDE7A (0.54) | MEN1KMT2AKDM4EMAPTGAA | |
| SCHEMBL6623045 | 0.81 | SRD5A2 (0.90) | MEN1KMT2AKDM4ESRD5A2MAPT | |
| SCHEMBL28561063 | 0.81 | SRD5A2 (0.90) | MEN1KMT2AKDM4ESRD5A2MAPT | |
| SCHEMBL1202826 | 0.80 | AKR1C3 (0.62) | MEN1KMT2AKDM4ESRD5A2ALDH1A1 | |
| SCHEMBL177838 | 0.79 | KDM4E (1.00) | MEN1KMT2AKDM4ESRD5A2MAPT | |
| SCHEMBL2427437 | 0.79 | XDH (0.58) | MEN1KMT2AKDM4ECHEK2ALDH1A1 | |
| SCHEMBL4694752 | 0.78 | HSPB1 (0.51) | MEN1KMT2AKDM4ESRD5A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298311-B1 | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-09 | — | — | EP | disclosed |