Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | GCK | P35557 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8737306 | 0.81 | MMP13 (0.58) | SMN1; SMN2ALDH1A1LMNAGCKMMP13 | |
| SCHEMBL8736963 | 0.81 | MMP13 (0.56) | SMN1; SMN2ALDH1A1LMNAGCKMMP13 | |
| SCHEMBL8737464 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1LMNAGCKMMP13 | |
| SCHEMBL8738321 | 0.74 | MAPK14 (0.76) | SMN1; SMN2ALDH1A1LMNAMMP13HPGD | |
| SCHEMBL257694 | 0.74 | MMP13 (0.71) | SMN1; SMN2GCKMMP13HPGDKMT2A | |
| SCHEMBL14336245 | 0.72 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1LMNAKMT2AGAA | |
| SCHEMBL6014130 | 0.71 | RAF1 (0.61) | SMN1; SMN2ALDH1A1LMNAGCKMMP13 | |
| SCHEMBL11668725 | 0.71 | HDAC8 (0.67) | SMN1; SMN2ALDH1A1LMNAGCKKMT2A | |
| SCHEMBL8737053 | 0.70 | MEN1 (0.60) | SMN1; SMN2ALDH1A1LMNAGCKKMT2A | |
| SCHEMBL14217726 | 0.70 | L3MBTL1 (0.56) | SMN1; SMN2GCKMMP13KMT2AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298311-B1 | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-09 | — | — | EP | disclosed |