Sugi Predict

Sugi Predict / Compounds / SCHEMBL6014376

SCHEMBL6014376

SCHEMBL6014376

C/C=C\N/C=C/Cc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 1/20 0.54
▸ CA1 P00915 1/20 0.42
▸ CA2 P00918 1/20 0.42
▸ ARG2 P78540 1/20 0.42
▸ MAPK1 P28482 1/20 0.37
▸ TOP1 P11387 1/20 0.36
▸ KCNH2 Q12809 2/20 0.35
▸ TP53 P04637 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ SIGMAR1 Q99720 1/20 0.33
▸ ATM Q13315 1/20 0.33
▸ TAAR1 Q96RJ0 1/20 0.33
▸ ADH1B P00325 1/20 0.32
▸ ADH1C P00326 1/20 0.32
▸ ADH1A P07327 1/20 0.32
▸ ADH7 P40394 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6014380 1.00 MAOB (0.54) MAOBCA1CA2ARG2MAPK1
SCHEMBL105172 0.78 MAOB (0.70) MAOBCA1CA2ARG2TOP1
SCHEMBL40701 0.78 MAOB (0.70) MAOBCA1CA2ARG2TOP1
Benzene SCHEMBL1226362 0.78 MAOB (0.70) MAOBCA1CA2ARG2TOP1
SCHEMBL2938308 0.78 MAOB (0.70) MAOBCA1CA2ARG2TOP1
Benzene SCHEMBL1226361 0.78 MAOB (0.70) MAOBCA1CA2ARG2TOP1
SCHEMBL28790914 0.78 MAOB (0.56) MAOBCA1CA2ARG2MAPK1
SCHEMBL13373175 0.77 MAOB (0.61) MAOBCA1CA2ARG2MAPK1
SCHEMBL21637548 0.77 MAOB (0.61) MAOBCA1CA2ARG2MAPK1
SCHEMBL9416674 0.72 MAOB (0.61) MAOBCA1CA2ARG2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7078406-B2 Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH & DEVELOPMENT, L.L.C. (US) 2006-07-18 — — US disclosed
US-20040248851-A1 Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes Life Technologies Corporation 2004-12-09 — — US disclosed
US-6815445-B2 FOR USE AS FLUORESCENCE DYES AND PROBES Life Technologies Corporation 2004-11-09 — — US disclosed
EP-1442027-A1 SUBSTITUTED DIPHENYLOXAZOLES, THE SYNTHESIS THEREOF, AND THE USE THEREOF AS FLUORESCENCE PROBES 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2004-08-04 — — EP disclosed
US-20030105111-A1 Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes 3-DIMENSIONAL PHARMACEUTICALS, INC. 2003-06-05 — — US disclosed
WO-2003031419-A1 SUBSTITUTED DIPHENYLOXAZOLES, THE SYNTHESIS THEREOF, AND THE USE THEREOF AS FLUORESCENCE PROBES 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2003-04-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040248851-A1 Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes DHFR, FPR1, CYP1A1 MAOB 402/4885CA1 1667/4885CA2 2598/4885
US-20030105111-A1 Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes DHFR, FPR1, CYP1A1 MAOB 402/4885CA1 1667/4885CA2 2598/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.