Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.59 |
| ▸ | TUBB | P07437 | 3/20 | 0.59 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.59 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.59 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.59 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.59 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.59 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.59 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.59 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.59 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.59 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938463 | 0.91 | TUBB4A (0.71) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL16240763 | 0.85 | TUBB4A (0.59) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL16240104 | 0.83 | TUBB4A (0.54) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL9156307 | 0.83 | ALDH1A1 (0.68) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL24074239 | 0.81 | TUBB4A (0.55) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL11683120 | 0.80 | PGR (0.50) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL2348081 | 0.78 | TUBB4A (0.68) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL5813270 | 0.78 | TUBB4A (0.80) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6627965 | 0.78 | TUBB4A (0.74) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL11684058 | 0.78 | KDM4E (0.44) | MEN1KMT2ATUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081472-B2 | Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them | K. U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2006-07-25 | — | — | US | disclosed |
| US-20040053911-A1 | Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2004-03-18 | — | — | US | disclosed |
| EP-1343758-A1 | SUBSTITUTED BIS-INDOLE DERIVATIVES USEFUL AS CONTRAST AGENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES FOR PRODUCING THEM | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002038546-A1 | SUBSTITUTED BIS-INDOLE DERIVATIVES USEFUL AS CONTRAST AGENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES FOR PRODUCING THEM | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2002-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053911-A1 | Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them | IDO1, IDO2, CNR1 | MEN1 41/4885KMT2A 2123/4885TUBB4A 3317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.