SCHEMBL6014766

SCHEMBL6014766

C=CCOC(=O)c1[nH]c2ccccc2c1C(c1ccc(OC)cc1)c1c(C(=O)OCC)[nH]c2ccccc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.61
MEN1 O00255 3/20 0.61
POLB P06746 2/20 0.61
APOBEC3A P31941 1/20 0.61
CASP6 P55212 1/20 0.61
APOBEC3G Q9HC16 1/20 0.61
HPGD P15428 2/20 0.52
LMNA P02545 2/20 0.52
HTT P42858 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
KDM4E B2RXH2 6/20 0.48
HSD17B10 Q99714 2/20 0.48
MAPK1 P28482 1/20 0.48
MAPT P10636 3/20 0.47
ALDH1A1 P00352 2/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
TUBB4A P04350 4/20 0.47
TUBB P07437 4/20 0.47
TUBA3C P0DPH7 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6014782 0.91 MEN1 (0.61) KMT2AMEN1POLBAPOBEC3ACASP6
SCHEMBL19661278 0.82 MEN1 (0.66) KMT2AMEN1POLBAPOBEC3ACASP6
SCHEMBL8475171 0.80 KDM4E (0.56) KMT2AMEN1POLBHPGDSMN1; SMN2
SCHEMBL7616574 0.80 KMT2A (0.52) KMT2AMEN1POLBAPOBEC3ACASP6
SCHEMBL8472591 0.80 MEN1 (0.62) KMT2AMEN1POLBHPGDSMN1; SMN2
SCHEMBL7003917 0.79 KMT2A (0.54) KMT2AMEN1POLBHPGDLMNA
SCHEMBL8471965 0.78 KDM4E (0.54) KMT2AMEN1POLBHPGDSMN1; SMN2
SCHEMBL8472332 0.78 KDM4E (0.54) KMT2AMEN1POLBHPGDSMN1; SMN2
SCHEMBL7002632 0.77 KMT2A (0.55) KMT2AMEN1POLBAPOBEC3ACASP6
SCHEMBL8472324 0.76 MEN1 (0.53) KMT2AMEN1POLBAPOBEC3ACASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1117518-B1 FABRICATION OF THREE-DIMENSIONAL OBJECTS STANFORD RES INST INT (US) 2006-03-08 EP disclosed
EP-1117518-A4 FABRICATION OF THREE-DIMENSIONAL OBJECTS STANFORD RES INST INT (US) 2003-01-29 EP disclosed
EP-1117518-A1 FABRICATION OF THREE-DIMENSIONAL OBJECTS SRI INTERNATIONAL (US) 2001-07-25 EP disclosed
WO-2000000335-A1 FABRICATION OF THREE-DIMENSIONAL OBJECTS SRI INTERNATIONAL (US) 2000-01-06 WO disclosed