Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.49 |
| ▸ | TUBB | P07437 | 3/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472324 | 0.90 | MEN1 (0.53) | KMT2AMEN1POLBGAAGABRA1 | |
| SCHEMBL7003917 | 0.82 | KMT2A (0.54) | KMT2AMEN1POLBGAATUBB4A | |
| SCHEMBL7006749 | 0.82 | TUBB4A (0.56) | KMT2AMEN1GAATUBB4ATUBB | |
| SCHEMBL8472591 | 0.81 | MEN1 (0.62) | KMT2AMEN1POLBGAATUBB4A | |
| SCHEMBL19661278 | 0.79 | MEN1 (0.66) | KMT2AMEN1POLBGAATUBB4A | |
| SCHEMBL7616574 | 0.79 | KMT2A (0.52) | KMT2AMEN1POLBTUBB4ATUBB | |
| SCHEMBL7005939 | 0.78 | ALDH1A1 (0.54) | KMT2AMEN1POLBGAATUBB4A | |
| SCHEMBL7004614 | 0.78 | ALDH1A1 (0.43) | KMT2AMEN1POLBGAATUBB4A | |
| SCHEMBL6014766 | 0.77 | KMT2A (0.61) | KMT2AMEN1POLBTUBB4ATUBB | |
| SCHEMBL8472895 | 0.77 | HTR6 (0.55) | KMT2AMEN1POLBGAATUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341761-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030895-A1 | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-η BINDING AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-18 | — | — | WO | disclosed |