Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR1F | P30939 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472324 | 0.85 | MEN1 (0.53) | KMT2AMEN1POLBAPOBEC3ACASP6 | |
| SCHEMBL8475171 | 0.85 | KDM4E (0.56) | KMT2AMEN1POLBKDM4EHTR6 | |
| SCHEMBL8472591 | 0.85 | MEN1 (0.62) | KMT2AMEN1POLBKDM4EHTR6 | |
| SCHEMBL8472895 | 0.84 | HTR6 (0.55) | KMT2AMEN1POLBAPOBEC3ACASP6 | |
| SCHEMBL8472332 | 0.83 | KDM4E (0.54) | KMT2AMEN1POLBKDM4EHTR6 | |
| SCHEMBL8471965 | 0.83 | KDM4E (0.54) | KMT2AMEN1POLBKDM4EHTR6 | |
| SCHEMBL19661278 | 0.83 | MEN1 (0.66) | KMT2AMEN1POLBAPOBEC3ACASP6 | |
| SCHEMBL8472571 | 0.80 | DRD2 (0.52) | KMT2AMEN1POLBAPOBEC3ACASP6 | |
| SCHEMBL6014766 | 0.80 | KMT2A (0.61) | KMT2AMEN1POLBAPOBEC3ACASP6 | |
| SCHEMBL7002632 | 0.79 | KMT2A (0.55) | KMT2AMEN1POLBAPOBEC3ACASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741132-B1 | INDOLE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-5891902-A | OSTEOPOROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0782988-A1 | INDOLE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-09 | — | — | EP | disclosed |
| EP-0741132-A1 | INDOLE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-11-06 | — | — | EP | disclosed |