Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083538 | 0.84 | PIK3CD (0.62) | PIK3CDPIK3CBPIK3CAKDM4EMAPT | |
| SCHEMBL1564559 | 0.82 | CHEK1 (0.50) | ALDH1A1LMNAHTTBTKIRAK4 | |
| SCHEMBL6015247 | 0.76 | KDM4E (0.48) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL6015267 | 0.76 | KMT2A (0.47) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL6015282 | 0.75 | KDM4E (0.46) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL6015246 | 0.75 | CHEK1 (0.48) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL13074181 | 0.73 | ALDH1A1 (0.46) | PIK3CDPIK3CBPIK3CAKDM4EMAPT | |
| SCHEMBL6015274 | 0.70 | KMT2A (0.44) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL6015237 | 0.69 | KDM4E (0.49) | KDM4EMAPTKMT2AATMCYP2D6 | |
| SCHEMBL6015245 | 0.67 | KDM4E (0.49) | KDM4EMAPTKMT2AATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732920-A2 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005066163-A2 | THIOPHENE DERIVATIVES AS CHK 1 INIHIBITORS | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |