Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ULK1 | O75385 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2449555 | 0.85 | F10 (0.64) | ALOX15NPC1RAB9AULK1POLB | |
| SCHEMBL2448229 | 0.85 | ULK1 (0.56) | ALOX15RAB9AULK1 | |
| SCHEMBL5205624 | 0.84 | NPC1 (0.69) | NPC1RAB9AHPGDHTTPOLB | |
| SCHEMBL23390173 | 0.83 | HTR2C (0.59) | ALOX15NPC1HTTULK1POLB | |
| SCHEMBL4564743 | 0.83 | ULK1 (0.64) | ALOX15RAB9AHPGDULK1 | |
| SCHEMBL8199064 | 0.83 | SMN1; SMN2 (0.64) | NPC1RAB9AHPGDHTTPOLB | |
| SCHEMBL3188745 | 0.83 | ENPP3 (0.69) | NPC1RAB9AHPGDHTTMTNR1A | |
| SCHEMBL2451482 | 0.82 | ULK1 (0.56) | NPC1RAB9AHTTULK1POLB | |
| SCHEMBL2449552 | 0.82 | ULK1 (0.56) | ALOX15NPC1RAB9AULK1POLB | |
| SCHEMBL2446479 | 0.81 | HPGD (0.66) | ALOX15HPGDULK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |