Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.58 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4022475 | 0.97 | HSD11B1 (0.61) | HSD11B1HSD11B2ALDH1A1TSHRCHRNB2 | |
| Hydrochloric Acid SCHEMBL6016934 | 0.97 | HSD11B1 (0.56) | HSD11B1HSD11B2ALDH1A1TSHRCHRNB2 | |
| SCHEMBL4830410 | 0.95 | HSD11B1 (0.52) | HSD11B1HSD11B2ALDH1A1TSHRCHRNB2 | |
| SCHEMBL28340951 | 0.95 | HSD11B1 (0.52) | HSD11B1HSD11B2ALDH1A1TSHRCHRNB2 | |
| Bromide SCHEMBL17009295 | 0.92 | HSD11B1 (0.50) | HSD11B1HSD11B2ALDH1A1TSHRCHRNB2 | |
| SCHEMBL30832718 | 0.89 | HSD11B1 (0.44) | HSD11B1HSD11B2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL2938030 | 0.86 | HSD11B1 (0.54) | HSD11B1L3MBTL3CNR2 | |
| SCHEMBL2824307 | 0.86 | HSD11B1 (0.54) | HSD11B1L3MBTL3CNR2 | |
| SCHEMBL8261093 | 0.86 | HSD11B1 (0.45) | HSD11B1HSD11B2ALDH1A1TSHRCHRNB2 | |
| SCHEMBL20958523 | 0.83 | HSD11B1 (0.42) | HSD11B1HSD11B2CHRNB2CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856735-B1 | FUSED BICYCLIC HETEROCYCLES AS THERAPEUTIC AGENTS | UNIV NEW YORK (US) | 2023-09-06 | — | — | EP | claimed |
| WO-2025049419-A1 | PYRAZOLYL COMPOUNDS AS EMOPAMIL BINDING PROTEIN INHIBITORS | GENZYME CORPORATION (US) | 2025-03-06 | — | — | WO | disclosed |
| CN-116685576-A | Cysteine protease inhibitors and methods of use thereof | 美商帕迪斯生物科学公司 | 2023-09-01 | — | — | CN | disclosed |
| EP-1713779-A1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | Sanofi-Aventis Deutschland GmbH (DE) | 2006-10-25 | — | — | EP | disclosed |
| EP-1615886-A1 | [C]-FUSED BICYCLIC PROLINE DERIVATIVES AND THEIR USE FOR TREATING ARTHRITIC CONDITIONS | Warner-Lambert Company LLC (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2005073199-A1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-08-11 | — | — | WO | disclosed |
| US-20050137215-A1 | [C]-fused bicyclic proline derivatives and their use for treating arthritic conditions | GUZZO PETER R (US) | 2005-06-23 | — | — | US | disclosed |
| WO-2004092134-A1 | [C]-FUSED BICYCLIC PROLINE DERIVATIVES AND THEIR USE FOR TREATING ARTHRITIC CONDITIONS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137215-A1 | [C]-fused bicyclic proline derivatives and their use for treating arthritic conditions | PPIC, PRAP1, PRRC2C | HSD11B1 2806/4885HSD11B2 2732/4885ALDH1A1 1447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.