Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.35 |
| ▸ | WNT3A | P56704 | 3/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015920 | 0.86 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL6015984 | 0.74 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1CYP2C19MAPT | |
| SCHEMBL3871239 | 0.73 | ATM (0.54) | ALDH1A1KMT2AGABRA1GABRB2MAPT | |
| SCHEMBL6015923 | 0.72 | KMT2A (0.62) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL6016007 | 0.72 | SMN1; SMN2 (0.40) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL6015634 | 0.72 | KMT2A (0.49) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL6016069 | 0.71 | KMT2A (0.64) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL6015996 | 0.69 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL6015749 | 0.69 | KMT2A (0.51) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL6015793 | 0.66 | KMT2A (0.46) | ALDH1A1KMT2AMEN1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |