Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 8/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015939 | 0.73 | NPC1 (0.49) | TSHRKDM4EGAATDP1NPC1 | |
| SCHEMBL6015867 | 0.71 | TSHR (0.53) | TSHRKDM4EGAATDP1NPC1 | |
| SCHEMBL8749756 | 0.62 | NPC1 (0.62) | TSHRKDM4EGAATDP1NPC1 | |
| SCHEMBL8749753 | 0.61 | RAB9A (0.54) | TSHRKDM4EGAATDP1NPC1 | |
| SCHEMBL10013763 | 0.61 | NPC1 (0.81) | TSHRNPC1RAB9AALDH1A1TRPM8 | |
| SCHEMBL6292262 | 0.61 | NPC1 (0.56) | TSHRKDM4EGAATDP1NPC1 | |
| SCHEMBL10682606 | 0.60 | LTB4R (0.58) | TSHRKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL5483907 | 0.60 | TSHR (0.63) | TSHRKDM4EGAATDP1NPC1 | |
| SCHEMBL11608373 | 0.60 | KDM4E (0.56) | TSHRKDM4EGAATDP1NPC1 | |
| SCHEMBL23358696 | 0.59 | POLB (0.69) | NPC1RAB9ATRPM8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |