Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016609 | 0.72 | SMN1; SMN2 (0.53) | GAAGSK3BMAP2K4ALDH1A1MAPT | |
| SCHEMBL14574212 | 0.70 | KDM4E (0.63) | GAAKDM4ESTAT3HIF1AGSK3B | |
| SCHEMBL4232664 | 0.70 | AR (0.55) | ARKDM4EMAP2K4ALDH1A1MAPT | |
| SCHEMBL26434989 | 0.69 | ALDH1A1 (0.47) | GAAKDM4EHIF1AALDH1A1CFTR | |
| SCHEMBL28104610 | 0.68 | ALDH1A1 (0.50) | GAAKDM4EHIF1AALDH1A1MAPT | |
| SCHEMBL2914448 | 0.68 | AXL (0.47) | KDM4EHSP90AB1GSK3BMAPTPARP1 | |
| SCHEMBL655527 | 0.68 | KDM4E (0.36) | PRMT5WDR77GAAMAPK1KDM4E | |
| SCHEMBL4326103 | 0.67 | ALDH1A1 (0.49) | GAAKDM4EHIF1AALDH1A1MAPT | |
| SCHEMBL657461 | 0.67 | ADCY10 (0.39) | PRMT5WDR77GAAKDM4EALDH1A1 | |
| SCHEMBL177123 | 0.67 | ALDH1A1 (0.67) | GAAKDM4EALDH1A1MAPTCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |