Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 5/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016509 | 0.92 | RXFP1 (0.42) | RXFP1MAPTTHRBLMNAGPBAR1 | |
| SCHEMBL6016692 | 0.90 | TACR1 (0.46) | RXFP1MAPTTHRBTACR1 | |
| SCHEMBL6016482 | 0.89 | RXFP1 (0.55) | RXFP1MAPTTHRBLMNATACR1 | |
| SCHEMBL6016647 | 0.87 | RXFP1 (0.44) | RXFP1MAPTTHRBLMNAGPBAR1 | |
| SCHEMBL7991077 | 0.85 | RXFP1 (0.42) | RXFP1MAPTTHRBTACR1 | |
| SCHEMBL7991781 | 0.85 | EPAS1 (0.43) | RXFP1THRBLMNATACR1 | |
| SCHEMBL6016417 | 0.84 | HSP90AB1 (0.52) | RXFP1MAPTHSP90AB1THRBMAPK1 | |
| SCHEMBL6016386 | 0.84 | RXFP1 (0.45) | RXFP1MAPTTHRBLMNATACR1 | |
| SCHEMBL6016361 | 0.80 | TACR1 (0.42) | RXFP1MAPTHSP90AB1GPBAR1TACR1 | |
| SCHEMBL7880582 | 0.80 | TACR1 (0.50) | GPBAR1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187815-B1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-02-08 | — | — | EP | disclosed |
| EP-1187815-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| US-6274588-B1 | NEUROKININ OR SUBSTANCE P ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| WO-2000073279-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |