Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016692 | 0.89 | TACR1 (0.46) | RXFP1MAPTTHRBTACR1 | |
| SCHEMBL6016647 | 0.89 | RXFP1 (0.44) | RXFP1MAPTTHRBTACR1 | |
| SCHEMBL6016462 | 0.89 | CETP (0.43) | CETPTACR1HTR7 | |
| SCHEMBL7991781 | 0.88 | EPAS1 (0.43) | RXFP1THRBTACR1 | |
| SCHEMBL6016386 | 0.87 | RXFP1 (0.45) | RXFP1MAPTTHRBTACR1 | |
| SCHEMBL6016360 | 0.85 | RXFP1 (0.44) | RXFP1MAPTTHRBTACR1 | |
| SCHEMBL6016482 | 0.83 | RXFP1 (0.55) | RXFP1MAPTTHRBTACR1TP53 | |
| SCHEMBL6016509 | 0.83 | RXFP1 (0.42) | RXFP1MAPTTHRBTACR1 | |
| SCHEMBL6866303 | 0.82 | CETP (0.53) | CETPTACR1HTR7 | |
| SCHEMBL6016587 | 0.82 | MAPT (0.50) | RXFP1MAPTTHRBPDE4BTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274588-B1 | NEUROKININ OR SUBSTANCE P ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |