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Formamide

Formamide

SCHEMBL6016424

FC(F)(F)Cc1cccc(-c2cccc(CC(F)(F)F)c2)c1.NC=O

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ AGXT P21549 3/20 0.45
▸ GGPS1 O95749 2/20 0.41
▸ PTPN5 P54829 4/20 0.38
▸ ABL1 P00519 1/20 0.37
▸ PRKCI P41743 1/20 0.37
▸ PTPN1 P18031 1/20 0.35
▸ AOC3 Q16853 2/20 0.35
▸ MAOB P27338 1/20 0.35
▸ CFD P00746 1/20 0.35
▸ TAAR1 Q96RJ0 1/20 0.34
▸ PRMT6 Q96LA8 1/20 0.34
▸ GRIA2 P42262 1/20 0.34
▸ MGLL Q99685 1/20 0.34
▸ BACE1 P56817 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13437611 0.77 ATM (0.34) GGPS1ABL1TAAR1BACE1
SCHEMBL533642 0.76 AGXT (0.41) AGXTGGPS1PTPN5ABL1PRKCI
SCHEMBL7141602 0.76 MAOA (0.45) MAOB
SCHEMBL15778664 0.74 MAOB (0.54) MAOBTAAR1
SCHEMBL7188782 0.72 ACP3 (0.34) GGPS1ABL1TAAR1
SCHEMBL16555198 0.70 HSD17B1 (0.40) AGXTGGPS1PTPN5ABL1GRIA2
SCHEMBL3647842 0.70 TAAR1 (0.52) AGXTMAOBTAAR1
SCHEMBL27432498 0.69 AGXT (0.47) AGXTGGPS1PTPN5PRKCIPTPN1
SCHEMBL28316824 0.69 PARP1 (0.52) MAOB
SCHEMBL23140929 0.68 IDO1 (0.48) TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187815-B1 4-PHENYL-PYRIMIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2006-02-08 — — EP claimed