SCHEMBL6016473

SCHEMBL6016473

CN1CCN(c2ncc(C(=O)O)c(-c3ccccc3)n2)CC1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 12/20 0.57
CASP1 P29466 12/20 0.57
CASP7 P55210 12/20 0.57
CYP1A2 P05177 10/20 0.57
USP2 O75604 10/20 0.57
HSD17B10 Q99714 10/20 0.57
HIF1A Q16665 7/20 0.57
GLA P06280 6/20 0.57
MAPT P10636 2/20 0.57
HPGD P15428 2/20 0.54
TSHR P16473 5/20 0.52
CYP2C9 P11712 4/20 0.52
KMT2A Q03164 2/20 0.52
MEN1 O00255 1/20 0.52
HRH4 Q9H3N8 3/20 0.51
HTR3A P46098 1/20 0.51
CYP2D6 P10635 2/20 0.50
LMNA P02545 2/20 0.50
ALOX15 P16050 1/20 0.50
CYP3A4 P08684 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4112958 0.89 ALDH1A1 (0.53) ALDH1A1CASP1CASP7CYP1A2USP2
SCHEMBL6016426 0.86 PTPN11 (0.53) ALDH1A1CASP1CASP7HSD17B10GLA
Hydrochloric Acid SCHEMBL3866277 0.85 PTPN11 (0.52) ALDH1A1CASP1CASP7HSD17B10GLA
SCHEMBL6016347 0.85 ALDH1A1 (0.54) ALDH1A1CASP1CASP7CYP1A2USP2
SCHEMBL4130476 0.85 TACR1 (0.59) ALDH1A1CASP1CASP7CYP1A2USP2
SCHEMBL6016398 0.84 ALDH1A1 (0.55) ALDH1A1CASP1CASP7CYP1A2USP2
SCHEMBL6016519 0.84 PTPN11 (0.57) ALDH1A1CASP1CASP7CYP1A2USP2
SCHEMBL4112070 0.84 HRH4 (0.49) ALDH1A1CASP1CASP7CYP1A2USP2
SCHEMBL4129695 0.84 TSHR (0.51) ALDH1A1CASP1CASP7CYP1A2USP2
SCHEMBL4118986 0.84 TACR1 (0.47) ALDH1A1CASP1CASP7CYP1A2USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187815-B1 4-PHENYL-PYRIMIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2006-02-08 EP disclosed
CN-1166643-C 4-phenyl-pyrimidine derivatives - 2004-09-15 CN disclosed
CN-1353697-A 4-phenyl-pyrimidine derivatives HOFFMANN LA ROCHE (CH) 2002-06-12 CN disclosed
EP-1187815-A1 4-PHENYL-PYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-03-20 EP disclosed
US-6274588-B1 NEUROKININ OR SUBSTANCE P ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS HOFFMANN-LA ROCHE INC. 2001-08-14 US disclosed
WO-2000073279-A1 4-PHENYL-PYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-12-07 WO disclosed