Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.33 |
| ▸ | HTR2B | P41595 | 5/20 | 0.33 |
| ▸ | HTR2A | P28223 | 6/20 | 0.33 |
| ▸ | HTR6 | P50406 | 4/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | CCKBR | P32239 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017056 | 0.83 | HTR2C (0.36) | HTR2CHTR2BHTR2AHTR6DRD3 | |
| SCHEMBL4420697 | 0.74 | HTR6 (0.32) | HTR6CCKBRBDKRB1 | |
| SCHEMBL6017214 | 0.67 | KMT2A (0.56) | HTR6 | |
| SCHEMBL6016995 | 0.67 | HTT (0.46) | — | |
| SCHEMBL7104439 | 0.60 | HTR2C (0.40) | HTR2CHTR2BHTR2A | |
| SCHEMBL11227084 | 0.59 | HTR2C (0.44) | HTR2CHTR2BHTR2ATP53 | |
| SCHEMBL4423058 | 0.59 | POLB (0.36) | HTR6 | |
| Hydrochloric Acid SCHEMBL11030525 | 0.58 | HTR2C (0.43) | HTR2CHTR2BHTR2ATP53 | |
| SCHEMBL4425141 | 0.58 | PKM (0.42) | HTR6 | |
| SCHEMBL390902 | 0.58 | CCR4 (0.40) | CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654258-A1 | SULFONYLDIHYDRO- BENZIMIDAZOLONE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005009996-A1 | SULFONYLDIHYDRO- BENZIMIDAZOLONE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-02-03 | — | — | WO | claimed |