Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 8/20 | 0.38 |
| ▸ | MMP12 | P39900 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 6/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017193 | 0.89 | PPARD (0.40) | PPARDMMP12PPARAS1PR1PPARG | |
| SCHEMBL6017244 | 0.86 | PPARD (0.45) | PPARDPPARAPPARGPTGER4KDM4E | |
| SCHEMBL5617216 | 0.81 | PPARD (0.40) | PPARDPPARAPPARGPTGER4KDM4E | |
| SCHEMBL6017252 | 0.79 | PPARD (0.47) | PPARDPPARAPPARG | |
| SCHEMBL5653757 | 0.78 | PPARD (0.41) | PPARDPPARAPPARGPTGER4KDM4E | |
| SCHEMBL5628280 | 0.77 | PPARD (0.43) | PPARDMMP12PPARAPPARGCHRM4 | |
| SCHEMBL1549780 | 0.76 | PPARD (0.55) | PPARDPPARA | |
| SCHEMBL5617395 | 0.76 | PPARD (0.44) | PPARDPPARAPPARGPTGER4KDM4E | |
| SCHEMBL1550371 | 0.75 | MMP12 (0.43) | PPARDMMP12DHODHCHRM4 | |
| SCHEMBL6064622 | 0.74 | PPARD (0.38) | PPARDPPARAPPARGPTGER4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |