Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 11/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 6/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017265 | 0.89 | PKM (0.42) | PPARDKDM4EPTGER4TRPV1ALDH1A1 | |
| SCHEMBL5617216 | 0.84 | PPARD (0.40) | PPARDKDM4EPTGER4PPARAPPARG | |
| SCHEMBL5617395 | 0.84 | PPARD (0.44) | PPARDKDM4EPTGER4PPARAPPARG | |
| SCHEMBL5617387 | 0.82 | PPARD (0.49) | PPARDPPARAPPARGNR1H2NR1H3 | |
| SCHEMBL6017244 | 0.81 | PPARD (0.45) | PPARDKDM4EPTGER4PPARAPPARG | |
| SCHEMBL6064607 | 0.80 | PPARD (0.41) | PPARDKDM4EPTGER4PPARAPPARG | |
| SCHEMBL6017193 | 0.80 | PPARD (0.40) | PPARDKDM4EPPARAPPARGTRPV1 | |
| SCHEMBL6064622 | 0.79 | PPARD (0.38) | PPARDKDM4EPTGER4PPARAPPARG | |
| SCHEMBL6065408 | 0.79 | PPARD (0.40) | PPARDKDM4EPPARAPPARGTRPV1 | |
| SCHEMBL6017170 | 0.78 | PPARD (0.38) | PPARDKDM4EPTGER4PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509996-A | — | — | 2007-04-19 | — | — | JP | claimed |
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | claimed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | claimed |