Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16990199 | 0.91 | TSHR (0.51) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL9544372 | 0.87 | POLB (0.53) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL9544370 | 0.87 | POLB (0.53) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL13758532 | 0.86 | ALDH1A1 (0.46) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL15417732 | 0.86 | ABCB1 (0.48) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL23532545 | 0.84 | TSHR (0.50) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL29930406 | 0.83 | MAPK1 (0.45) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL13613076 | 0.83 | POLB (0.48) | TSHRALDH1A1CYP3A4FKBP1AABCB1 | |
| SCHEMBL21273903 | 0.83 | ABCB1 (0.54) | FKBP1AABCB1AGTR2BDKRB2KLK7 | |
| SCHEMBL8863233 | 0.83 | POLB (0.56) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660443-A2 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT | SCHERING CORPORATION (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016876-A2 | CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT | SCHERING CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |