Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5617095 | 0.78 | KDM4E (0.40) | PPARGPPARAPPARDTRPV1LTB4R | |
| SCHEMBL6017182 | 0.75 | PKM (0.40) | PPARGPPARAPPARDTRPV1L3MBTL1 | |
| SCHEMBL4424891 | 0.71 | PPARG (0.50) | PPARGPPARAPPARDLTB4R | |
| SCHEMBL6028635 | 0.70 | PPARG (0.51) | PPARGPPARAPPARDMCL1 | |
| SCHEMBL4432117 | 0.69 | PPARG (0.50) | PPARGPPARAPPARDL3MBTL1 | |
| SCHEMBL5669635 | 0.69 | TRPV3 (0.38) | KDM1ATRPV3 | |
| SCHEMBL1549656 | 0.68 | TRPV3 (0.45) | TRPV3 | |
| SCHEMBL1549173 | 0.68 | TRPV3 (0.40) | KDM1ATRPV3 | |
| SCHEMBL6017246 | 0.68 | PPARG (0.43) | PPARGPPARAPPARD | |
| SCHEMBL1549836 | 0.68 | TRPV3 (0.38) | KDM1ATRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |