Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 13/20 | 0.51 |
| ▸ | EGFR | P00533 | 8/20 | 0.51 |
| ▸ | FECH | P22830 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.51 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.50 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | GCK | P35557 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564348 | 0.87 | ERBB2 (0.66) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL24832693 | 0.77 | ERBB2 (0.68) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL3387660 | 0.76 | ERBB2 (0.51) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL3387665 | 0.76 | ERBB2 (0.51) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL30576206 | 0.76 | ERBB2 (0.53) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL25429034 | 0.76 | ERBB2 (0.53) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL24569330 | 0.76 | ERBB2 (0.67) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL29888726 | 0.76 | ERBB2 (0.67) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4866251 | 0.76 | EGFR (0.67) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL26003790 | 0.76 | ERBB2 (0.46) | ERBB2EGFRFECHCDK8MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664028-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026151-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |