Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 8/20 | 0.37 |
| ▸ | TYK2 | P29597 | 8/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661853 | 0.78 | ALDH1A1 (0.39) | HPGDTYK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4710625 | 0.72 | HPGD (0.47) | GSK3BHPGDULK1NPC1LMNA | |
| SCHEMBL4710626 | 0.72 | HPGD (0.47) | GSK3BHPGDULK1NPC1LMNA | |
| SCHEMBL8915581 | 0.70 | ALDH1A1 (0.43) | LMNA | |
| SCHEMBL28680870 | 0.69 | HPGD (0.49) | GSK3BHPGDJAK2TYK2NPC1 | |
| SCHEMBL14818761 | 0.69 | SMN1; SMN2 (0.57) | NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL18640737 | 0.68 | DHODH (0.54) | GSK3BHPGDJAK2TYK2NPC1 | |
| SCHEMBL1554464 | 0.68 | F11 (0.44) | GSK3BHPGDJAK2TYK2NPC1 | |
| SCHEMBL1554462 | 0.68 | F11 (0.44) | GSK3BHPGDJAK2TYK2NPC1 | |
| SCHEMBL21366833 | 0.67 | KDM4E (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720874-A1 | 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Bioaxone Therapeutique Inc. (CA) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005080394-A1 | 4-SUBSTITUTED PIPERIDINE DERIVATIVES | BIOAXONE THERAPEUTIQUE INC. (CA) | 2005-09-01 | — | — | WO | disclosed |
| EP-1546108-A1 | 1,4-SUBSTITUTED CYCLOHEXANE DERIVATIVES | UNIVERSITE DE MONTREAL (CA) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004022541-A1 | 1,4-SUBSTITUTED CYCLOHEXANE DERIVATIVES | UNIVERSITE DE MONTREAL (CA) | 2004-03-18 | — | — | WO | disclosed |
| EP-0641781-B1 | 4-AMINO(ALKYL)CYCLOHEXANE-1-CARBOXAMIDE COMPOUND AND USE THEREOF | YOSHITOMI PHARMACEUTICAL (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-5478838-A | Treating hypertension, angina pectoris, asthma, improving peripheral circulation | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| EP-0641781-A1 | 4-AMINO(ALKYL)CYCLOHEXANE-1-CARBOXAMIDE COMPOUND AND USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |