Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 10/20 | 0.47 |
| ▸ | RARB | P10826 | 10/20 | 0.47 |
| ▸ | RARG | P13631 | 10/20 | 0.47 |
| ▸ | RXRA | P19793 | 4/20 | 0.47 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328531 | 0.83 | RARA (0.44) | RARARARBRARGRXRASSTR5 | |
| SCHEMBL18785164 | 0.83 | RARA (0.44) | RARARARBRARGRXRASSTR5 | |
| SCHEMBL7932915 | 0.81 | RARA (0.43) | RARARARBRARGRXRASSTR5 | |
| SCHEMBL7935617 | 0.81 | RARA (0.49) | RARARARBRARGRXRASSTR5 | |
| SCHEMBL6146438 | 0.79 | RARA (0.51) | RARARARBRARGRXRASSTR5 | |
| SCHEMBL669879 | 0.78 | RARB (0.59) | RARARARBRARGRXRASSTR5 | |
| SCHEMBL4440994 | 0.77 | RARA (0.56) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL7224461 | 0.75 | RARA (0.47) | RARARARBRARGRXRASSTR5 | |
| SCHEMBL3263389 | 0.75 | ALDH1A1 (0.37) | RARARARBRARGRXRASSTR5 | |
| SCHEMBL18740982 | 0.74 | RARA (0.41) | RARARARBRARGRXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704139-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RAR y RETINOID RECEPTORS | Allergan, Inc. (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005066116-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RARϜ RETINOID RECEPTORS | ALLERGAN, INC. (US) | 2005-07-21 | — | — | WO | disclosed |