Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 3/20 | 0.56 |
| ▸ | RARB | P10826 | 3/20 | 0.56 |
| ▸ | RARG | P13631 | 3/20 | 0.56 |
| ▸ | RXRA | P19793 | 7/20 | 0.54 |
| ▸ | RXRB | P28702 | 5/20 | 0.54 |
| ▸ | RXRG | P48443 | 3/20 | 0.54 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.51 |
| ▸ | CYP26B1 | Q9NR63 | 7/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245647 | 0.89 | RARA (0.46) | RARARARBRARGRXRARXRB | |
| SCHEMBL8795908 | 0.84 | CYP26B1 (0.51) | RARARARBRARGRXRARXRB | |
| SCHEMBL11648365 | 0.84 | RARA (0.51) | RARARARBRARGRXRARXRB | |
| SCHEMBL6431035 | 0.84 | RARA (0.51) | RARARARBRARGRXRARXRB | |
| SCHEMBL18740982 | 0.82 | RARA (0.41) | RARARARBRARGRXRARXRB | |
| Formaldehyde SCHEMBL9052614 | 0.82 | RARA (0.44) | RARARARBRARGRXRARXRB | |
| SCHEMBL18741112 | 0.81 | ESR2 (0.41) | RARARARBRARGRXRARXRB | |
| SCHEMBL8330612 | 0.80 | RARA (0.58) | RARARARBRARGRXRARXRB | |
| SCHEMBL6017346 | 0.80 | RXRA (0.39) | RARARARBRARGRXRARXRB | |
| SCHEMBL7143189 | 0.79 | CYP26B1 (0.47) | RARARARBRARGRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3152190-A1 | 18-20 MEMBER BI-POLYCYCLIC COMPOUNDS | Haro Pharmaceutical Inc. (US) | 2017-04-12 | — | — | EP | disclosed |
| WO-2015188015-A1 | 18-20 MEMBER BI-POLYCYCLIC COMPOUNDS | HARO PHARMACEUTICAL INC. (US) | 2015-12-10 | — | — | WO | disclosed |
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |
| EP-1704139-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RAR y RETINOID RECEPTORS | Allergan, Inc. (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005066116-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RARϜ RETINOID RECEPTORS | ALLERGAN, INC. (US) | 2005-07-21 | — | — | WO | disclosed |
| US-4326055-A | ANTITUMOR AGENTS, SKIN DISORDERS, RHEUMATIC DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1982-04-20 | — | — | US | disclosed |