Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 10/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 9/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6018023 | 0.92 | IDO1 (0.43) | ABL1RIN1ENPP3ENPP1ENPP2 | |
| SCHEMBL5037857 | 0.83 | ENPP3 (0.40) | ENPP3ENPP1ENPP2KDM4EMEN1 | |
| SCHEMBL5037793 | 0.83 | ENPP3 (0.39) | ENPP3ENPP1ENPP2MAPTHTT | |
| SCHEMBL5042961 | 0.82 | HTR6 (0.45) | KDM4EMEN1BLMKMT2ATDP1 | |
| SCHEMBL5037789 | 0.82 | ENPP3 (0.37) | ENPP3ENPP1ENPP2MAPTHSD17B10 | |
| SCHEMBL5033423 | 0.82 | ENPP3 (0.40) | ENPP3ENPP1ENPP2MAPTKDM4E | |
| SCHEMBL5042870 | 0.82 | ENPP3 (0.48) | ENPP3ENPP1ENPP2TDP1 | |
| SCHEMBL5036480 | 0.82 | NPC1 (0.53) | ENPP3ENPP1ENPP2MAPTALDH1A1 | |
| SCHEMBL7145205 | 0.81 | ENPP3 (0.36) | ENPP3ENPP1ENPP2MAPTHTT | |
| SCHEMBL5037777 | 0.81 | ENPP3 (0.52) | ENPP3ENPP1ENPP2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041668-B2 | Substituted benzimidazole compounds and their use for the treatment of cancer | AVENTIS PHARMA S.A. (FR) | 2006-05-09 | — | — | US | disclosed |
| US-20050014811-A1 | Substituted benzimidazole compounds and their use for the treatment of cancer | AVENTIS PHARMA S.A. (FR) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014811-A1 | Substituted benzimidazole compounds and their use for the treatment of cancer | CDKL3, CCNL2, CDKL1 | ABL1 83/4885RIN1 1508/4885ENPP3 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.