Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 17/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 8/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6021912 | 0.86 | CHRM2 (0.56) | CHRM2CD274 | |
| SCHEMBL6022146 | 0.85 | SPHK1 (0.39) | CD274PDCD1SPHK1SCN3A | |
| SCHEMBL5280124 | 0.83 | CHRM2 (0.46) | CHRM2CD274PDCD1 | |
| SCHEMBL4692594 | 0.82 | CHRM2 (0.42) | CHRM2 | |
| SCHEMBL4694973 | 0.81 | MCHR1 (0.40) | CHRM2 | |
| SCHEMBL4694020 | 0.81 | CHRM2 (0.40) | CHRM2 | |
| SCHEMBL4695275 | 0.80 | CHRM2 (0.35) | CHRM2 | |
| SCHEMBL4692420 | 0.78 | MCHR1 (0.38) | CHRM2 | |
| SCHEMBL5273742 | 0.77 | NAMPT (0.35) | CHRM2CD274 | |
| SCHEMBL2639275 | 0.76 | CHRM2 (0.45) | CHRM2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723114-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087738-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | disclosed |