Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114219 | 0.75 | ALDH1A1 (0.48) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL17911639 | 0.71 | ALDH1A1 (0.43) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL232744 | 0.71 | ALDH1A1 (0.43) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL5518922 | 0.71 | ALDH1A1 (0.50) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL533954 | 0.71 | CYP1A2 (0.46) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL232112 | 0.71 | CYP2A6 (0.46) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL232693 | 0.71 | CYP2A6 (0.43) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL232794 | 0.71 | ALDH1A1 (0.43) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL20507044 | 0.71 | ALDH1A1 (0.43) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 | |
| SCHEMBL219753 | 0.71 | CYP2A6 (0.46) | ALDH1A1CYP2A6HSD17B10TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144993-B2 | Process for the preparation of 4-methyl-7-aminoquinolones | CIBA SPECIALTY CHEMICALS CORP. (US) | 2006-12-05 | — | — | US | disclosed |
| US-20050222397-A1 | Process for the preparation of 4-methyl-7-aminoquinolones | CIBA SPECIALTY CHEMICALS CORP. | 2005-10-06 | — | — | US | disclosed |
| EP-1453809-A1 | PROCESS FOR THE PREPARATION OF 4-METHYL-7-AMINOQUINOLONES | Ciba SC Holding AG (CH) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050089-A1 | PROCESS FOR THE PREPARATION OF 4-METHYL-7-AMINOQUINOLONES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2003-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222397-A1 | Process for the preparation of 4-methyl-7-aminoquinolones | CBR1, CBR3, MRPL21 | ALDH1A1 2050/4885CYP2A6 87/4885HSD17B10 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.