Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropyl Alcohol SCHEMBL811815 | 0.90 | LMNA (0.50) | LMNATDP1ALDH1A1TSHRMAPT | |
| SCHEMBL811107 | 0.89 | LMNA (0.54) | LMNATDP1ALDH1A1TSHRMAPT | |
| SCHEMBL11816713 | 0.87 | LMNA (0.52) | LMNATDP1ALDH1A1TSHRMAPT | |
| SCHEMBL6578392 | 0.82 | LMNA (0.53) | LMNAALDH1A1TSHRMAPTMAPK1 | |
| Propylene Glycol SCHEMBL18393442 | 0.82 | TSHR (0.54) | LMNATDP1ALDH1A1TSHRMAPT | |
| Hexane SCHEMBL8012017 | 0.80 | LMNA (0.71) | LMNAALDH1A1TSHRMAPTMAPK1 | |
| SCHEMBL72471 | 0.80 | LMNA (0.62) | LMNAALDH1A1TSHRMAPTNOTUM | |
| SCHEMBL1896624 | 0.79 | ALDH1A1 (0.43) | LMNATDP1ALDH1A1TSHRMAPT | |
| SCHEMBL4567081 | 0.79 | ALDH1A1 (0.43) | LMNATDP1ALDH1A1TSHRMAPT | |
| SCHEMBL1898675 | 0.79 | ALDH1A1 (0.43) | LMNATDP1ALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925738-B1 | CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF | GFBIOCHEMICALS LTD (MT) | 2018-01-10 | — | — | EP | disclosed |
| US-9156809-B2 | Carboxy ester ketals, methods of manufacture, and uses thereof | SEGETIS, INC. (US) | 2015-10-13 | — | — | US | disclosed |
| EP-2603565-B1 | LATEX COATING COMPOSITIONS INCLUDING CARBOXY ESTER KETAL COALESCENTS, METHODS OF MANUFACTURE, AND USES THEREOF | SEGETIS INC (US) | 2015-10-07 | — | — | EP | disclosed |
| EP-2925738-A1 | CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF | Segetis, Inc. (US) | 2015-10-07 | — | — | EP | disclosed |
| US-9074065-B2 | Latex coating compositions including carboxy ester ketal coalescents, methods of manufacture, and uses thereof | SEGETIS, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| WO-2014085609-A1 | CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF | SEGETIS, INC. (US) | 2014-06-05 | — | — | WO | disclosed |
| US-20140147395-A1 | CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF | SEGETIS, INC. (US) | 2014-05-29 | — | — | US | disclosed |
| CN-103052691-B | Latex coating compositions including carboxy ester ketal coalescents, methods of manufacture, and uses thereof | SEGETIS INC | 2014-05-28 | — | — | CN | disclosed |
| EP-2603565-A2 | LATEX COATING COMPOSITIONS INCLUDING CARBOXY ESTER KETAL COALESCENTS, METHODS OF MANUFACTURE, AND USES THEREOF | Segetis, Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| CN-103052691-A | Latex coating compositions including carboxy ester ketal coalescents, methods of manufacture, and uses thereof | SEGETIS INC | 2013-04-17 | — | — | CN | disclosed |
| WO-2012021826-A2 | LATEX COATING COMPOSITIONS INCLUDING CARBOXY ESTER KETAL COALESCENTS, METHODS OF MANUFACTURE, AND USES THEREOF | SEGETIS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
| US-20120041110-A1 | LATEX COATING COMPOSITIONS INCLUDING CARBOXY ESTER KETAL COALESCENTS, METHODS OF MANUFACTURE, AND USES THEROF | SEGETIS, INC. (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140147395-A1 | CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF | C9, C5, C1S | LMNA 2576/4885TDP1 2702/4885ALDH1A1 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.