Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 7/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.50 |
| ▸ | MMP2 | P08253 | 5/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172303 | 0.84 | ADAM10 (0.55) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3458022 | 0.78 | ALDH1A1 (0.58) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3457383 | 0.78 | ALDH1A1 (0.58) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL3458021 | 0.78 | ALDH1A1 (0.58) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2173008 | 0.76 | NAMPT (0.43) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2239831 | 0.74 | NAMPT (0.66) | NAMPTALDH1A1GRM5GRM1PDK4 | |
| SCHEMBL3458400 | 0.74 | ALDH1A1 (0.58) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL16393743 | 0.73 | ADAM10 (0.47) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2172713 | 0.73 | ADAM10 (0.57) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL2172725 | 0.73 | ADAM10 (0.57) | ADAM10ERBB2MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |