Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ADAM10 | O14672 | 8/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.47 |
| ▸ | MMP2 | P08253 | 6/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3458021 | 1.00 | ALDH1A1 (0.58) | ALDH1A1GAAADAM10ERBB2MMP2 | |
| SCHEMBL3457383 | 1.00 | ALDH1A1 (0.58) | ALDH1A1GAAADAM10ERBB2MMP2 | |
| SCHEMBL3458400 | 0.87 | ALDH1A1 (0.58) | ALDH1A1GAAADAM10ERBB2MMP2 | |
| SCHEMBL3456865 | 0.82 | ADAM10 (0.48) | ALDH1A1GAAADAM10ERBB2MMP2 | |
| SCHEMBL3458463 | 0.82 | ALDH1A1 (0.50) | ALDH1A1GAAADAM10ERBB2MMP2 | |
| SCHEMBL6023765 | 0.78 | ADAM10 (0.50) | ALDH1A1GAAADAM10ERBB2MMP2 | |
| SCHEMBL3457901 | 0.77 | SIGMAR1 (0.51) | ALDH1A1ADAM10ERBB2MMP2MMP9 | |
| SCHEMBL3457143 | 0.77 | SIGMAR1 (0.51) | ALDH1A1ADAM10ERBB2MMP2MMP9 | |
| SCHEMBL2172303 | 0.77 | ADAM10 (0.55) | ALDH1A1GAAADAM10ERBB2MMP2 | |
| SCHEMBL3457688 | 0.75 | ADAM10 (0.69) | ADAM10ERBB2MMP2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264030-A1 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | Incyte Corporation (US) | 2010-12-22 | — | — | EP | disclosed |