Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6024246 | 1.00 | ALOX5 (0.50) | ALOX5LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL9003247 | 0.82 | MEN1 (0.46) | SMN1; SMN2MAPK1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL9003251 | 0.82 | MEN1 (0.46) | SMN1; SMN2MAPK1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL1858472 | 0.80 | ALOX5 (0.56) | ALOX5HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL304579 | 0.80 | L3MBTL1 (0.55) | ALOX5HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL304577 | 0.80 | L3MBTL1 (0.55) | ALOX5HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11133561 | 0.78 | ALOX5 (0.53) | ALOX5LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL13237271 | 0.77 | ALOX5 (0.50) | ALOX5LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL260297 | 0.77 | ALOX5 (0.76) | ALOX5HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10475121 | 0.76 | ALOX15 (0.41) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115608-B2 | Pyridinone and pyridinethione derivatives having HIV inhibiting properties | CENTRE NATIONAL DE LA RECHERCHE SCHENTIFIQUE (FR) | 2006-10-03 | — | — | US | disclosed |
| EP-1318995-B1 | PYRIDINONE AND PYRIDINETHIONE DERIVATIVES HAVING HIV INHIBITING PROPERTIES | CENTRE NAT RECH SCIENT (FR) | 2006-03-08 | — | — | EP | disclosed |
| US-20040229847-A1 | Pyridinone and pyridinethione derivatives having hiv inhibiting properties | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2004-11-18 | — | — | US | disclosed |
| EP-1318995-A2 | PYRIDINONE AND PYRIDINETHIONE DERIVATIVES HAVING HIV INHIBITING PROPERTIES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024650-A2 | PYRIDINONE AND PYRIDINETHIONE DERIVATIVES HAVING HIV INHIBITING PROPERTIES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229847-A1 | Pyridinone and pyridinethione derivatives having hiv inhibiting properties | CYP2B6, CYP2S1, CYP2D6 | ALOX5 10/4885LMNA 2432/4885HDAC3 2724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.