Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CD38 | P28907 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423510 | 0.82 | ALDH1A1 (0.47) | ALDH1A1 | |
| SCHEMBL30536226 | 0.69 | CDK2 (0.42) | MAPK8CD38 | |
| SCHEMBL4433674 | 0.69 | ALDH1A1 (0.48) | ALDH1A1 | |
| SCHEMBL27681785 | 0.68 | KMT2A (0.37) | ALDH1A1 | |
| SCHEMBL20338401 | 0.65 | TXNRD1 (0.54) | — | |
| SCHEMBL30578514 | 0.65 | MEN1 (0.41) | MAPK8ALDH1A1 | |
| SCHEMBL30536189 | 0.65 | CYP3A4 (0.44) | ALDH1A1 | |
| SCHEMBL5043832 | 0.64 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL4425770 | 0.64 | POLB (0.52) | ALDH1A1 | |
| SCHEMBL30536210 | 0.63 | HCAR3 (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723116-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co. KGaA (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005082856-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2005-09-09 | — | — | WO | disclosed |