SCHEMBL6028448

SCHEMBL6028448

O=C(Cc1ccccc1)C1=C(O)C(CCc2ccccc2)=NC1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.38
MAPT P10636 2/20 0.38
DAO P14920 2/20 0.38
GAA P10253 2/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
AKR1B1 P15121 1/20 0.38
SLC5A1 P13866 1/20 0.38
SLC5A2 P31639 1/20 0.38
FFAR1 O14842 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
XIAP P98170 2/20 0.37
GPR84 Q9NQS5 1/20 0.37
FNTA P49354 1/20 0.37
FNTB P49356 1/20 0.37
SRD5A2 P31213 2/20 0.36
ALDH1A1 P00352 1/20 0.36
IDO1 P14902 1/20 0.36
RAB9A P51151 1/20 0.36
RNASEH1 O60930 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6028657 0.88 ALOX5 (0.45) DAOAKR1B1FFAR1
SCHEMBL6029060 0.86 TDP1 (0.50) LMNAMAPTCES1L3MBTL1ALDH1A1
SCHEMBL6028495 0.83 LMNA (0.38) LMNAMAPTDAOGAASLC5A1
SCHEMBL6028416 0.82 GAA (0.37) MAPTDAOGAASLC5A1SLC5A2
SCHEMBL6028363 0.81 TP53 (0.43) MAPTDAO
SCHEMBL6028547 0.79 ADORA2A (0.44) LMNAMAPTDAOGAASLC5A1
SCHEMBL6028905 0.79 KDM4E (0.44) LMNAMAPTL3MBTL1ALDH1A1
SCHEMBL6028438 0.79 NPC1 (0.54) MAPTSLC5A1SLC5A2FFAR1L3MBTL1
SCHEMBL6027901 0.78 POLB (0.47) LMNAMAPTGAAALDH1A1RAB9A
SCHEMBL6028324 0.77 SCN1A (0.36) MAPTDAOGAASLC5A1SLC5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1689729-A1 TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE F. Hoffmann-La Roche AG (CH) 2006-08-16 EP claimed
WO-2005058857-A1 TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE F. HOFFMANN-LA ROCHE AG (CH) 2005-06-30 WO claimed
EP-1689729-A1 TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE F. Hoffmann-La Roche AG (CH) 2006-08-16 EP disclosed
WO-2005058857-A1 TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE F. HOFFMANN-LA ROCHE AG (CH) 2005-06-30 WO disclosed