Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028010 | 0.92 | JAK2 (0.35) | ENPP2JAK2JAK1TYK2JAK3 | |
| SCHEMBL6028623 | 0.87 | P2RX7 (0.34) | JAK2JAK1TYK2JAK3P2RX7 | |
| Acetic Acid SCHEMBL6029259 | 0.79 | F10 (0.43) | — | |
| SCHEMBL6032377 | 0.73 | F10 (0.33) | — | |
| SCHEMBL6077849 | 0.72 | ENPP2 (0.36) | ENPP2 | |
| SCHEMBL6077842 | 0.72 | ENPP2 (0.36) | ENPP2 | |
| SCHEMBL6028754 | 0.71 | — | — | |
| SCHEMBL6028546 | 0.69 | F10 (0.33) | ENPP2JAK2JAK1TYK2JAK3 | |
| SCHEMBL6030782 | 0.64 | F10 (0.35) | ENPP2JAK2JAK1TYK2JAK3 | |
| SCHEMBL6077622 | 0.64 | F10 (0.35) | ENPP2JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706396-A1 | N-(4-CARBAMIMIDOYL-BENZYL)-2-ALKOXY-2-HETEROCYCLYL ACETAMIDES AS INHIBITORS OF THE FORMATION OF COAGULATION FACTORS XA, IXA AND THROMBIN INDUCED BY FACTOR VIIA | F.HOFFMANN-LA ROCHE AG (CH) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005058868-A1 | N-(4-CARBAMIMIDOYL-BENZYL) -2-ALKOXY-2-HETEROCYCLYL ACETAMIDES AS INHIBITORS OF THE FORMATION OF COAGULATION FACTORS XA, IXA AND THROMBIN INDUCED BY FACTOR VIIA | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |