Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.64 |
| ▸ | GAA | P10253 | 7/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 6/20 | 0.64 |
| ▸ | CASP1 | P29466 | 5/20 | 0.64 |
| ▸ | CASP7 | P55210 | 4/20 | 0.64 |
| ▸ | GLA | P06280 | 3/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 4/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3320598 | 0.91 | ALDH1A1 (0.66) | NPSR1KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL3324485 | 0.88 | KDM4E (0.73) | NPSR1KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL5815747 | 0.87 | NPSR1 (0.67) | NPSR1KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL10953920 | 0.85 | KDM4E (0.77) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL5823596 | 0.85 | HTR1A (0.51) | NPSR1KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL20657021 | 0.84 | KDM4E (0.77) | NPSR1KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL3325287 | 0.84 | KDM4E (0.72) | NPSR1KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL7383959 | 0.82 | KDM4E (0.72) | NPSR1KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL3324426 | 0.81 | KDM4E (0.66) | NPSR1KDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL3325897 | 0.81 | KDM4E (0.68) | NPSR1KDM4EALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663227-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | Synta Pharmaceuticals Corporation (US) | 2006-06-07 | — | — | EP | claimed |
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SYNTA PHARMACEUTICAL CORP. | 2005-09-15 | — | — | US | claimed |
| WO-2005025507-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | SYNTA PHAMACEUTICALS CORP. (US) | 2005-03-24 | — | — | WO | claimed |
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SYNTA PHARMACEUTICAL CORP. | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SLC5A2, SLC5A1, QDPR | NPSR1 703/4885KDM4E 2337/4885ALDH1A1 416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.