SCHEMBL6028824

SCHEMBL6028824

Cc1ccc2[nH]cc(CCNC(N)=S)c2c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 2/20 0.70
MTNR1B P49286 2/20 0.70
HTR1D P28221 1/20 0.61
HTR2A P28223 1/20 0.61
MAPT P10636 5/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
POLB P06746 1/20 0.60
GFER P55789 1/20 0.58
ALOX12 P18054 2/20 0.56
HTT P42858 1/20 0.56
ALDH1A1 P00352 2/20 0.56
GAA P10253 1/20 0.56
HPGD P15428 1/20 0.56
TDP1 Q9NUW8 2/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
MAPK1 P28482 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
PTGS1 P23219 1/20 0.55
PTGS2 P35354 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10310452 0.86 MTNR1A (0.70) MTNR1AMTNR1BHTR1DHTR2AMAPT
SCHEMBL6028502 0.85 SPR (0.67) HTR1DHTR2AMAPTALDH1A1HPGD
SCHEMBL6028185 0.84 MTNR1A (0.68) MTNR1AMTNR1BHTR2ASMN1; SMN2GFER
SCHEMBL6029341 0.83 MTNR1A (0.78) MTNR1AMTNR1BHTR1DHTR2AMAPT
SCHEMBL17211923 0.83 MTNR1A (0.76) MTNR1AMTNR1BMAPTSMN1; SMN2POLB
SCHEMBL31543697 0.82 MTNR1A (1.00) MTNR1AMTNR1BMAPTSMN1; SMN2POLB
SCHEMBL1771902 0.82 MTNR1A (1.00) MTNR1AMTNR1BMAPTSMN1; SMN2POLB
SCHEMBL20258534 0.82 MTNR1A (0.64) MTNR1AMTNR1BHTR1DHTR2AMAPT
SCHEMBL5149801 0.81 MTNR1A (0.70) MTNR1AMTNR1BHTR1DHTR2AMAPT
SCHEMBL6028397 0.80 IDO1 (0.68) HTR2AMAPTSMN1; SMN2POLBALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1709040-A2 FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE Sirenade Pharmaceuticals AG (DE) 2006-10-11 EP disclosed
WO-2005068458-A2 FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE SIRENADE PHARMACEUTICALS AG (DE) 2005-07-28 WO disclosed